Ketones for Metabolic Health, Brain Function, & Fertility with Latt Mansor

Dr. Mindy   Nd on this episode of The Resetter Podcast, I bring you Dr. Latt Mansor. nNow a couple things to know about Dr Latt and the conversation you're about to hear. For starters, we're gonna dive deep into the concept of a ketone. So Dr lat holds a PhD in physiology, anatomy and genetics from the University of Oxford. So he is brilliant, and he has really mastered the use of ketones when it comes to performance. So I loved this conversation on so many levels because A, it gave me some new insight into how we might look at ketones and and its effect on all aspects of our life, not just our health, but B, what Dr lat brings to us is what we call an exogenous ketone. And an exogenous ketone means that you actually are not producing it on the inside of your body. You're actually taking it from an outside source. Now, in full transparency, I want you to know that I have typically been against exogenous ketones, but Dr lat, he has changed my opinion based off the science that he is bringing us. So if you've been one of those people who have messaged me have wondered about exogenous ketones, where they fit in. This is the conversation for you. There were a couple of my big takeaways on this, one of which is how we can use exogenous ketones in the Fed state, so this isn't in the fasted state. How do we eat a meal and then use an exogenous ketone to help stabilize blood sugar? That blew my mind. I also loved how he looks at ketones for recovery from exercise. And then, as I said, How can we lean into these exogenous ketones for just overall performance in our day to day activities? So Dr lack completely changed my opinion of exogenous ketones, and you're about to hear why. Plus, for all you science nerds that want to know the research, Dr lat will bring it to you. So enjoy. This is definitely a conversation that was needed, and I'm so excited that I got to have this with Dr lat, because not only, as you will see, he's incredibly brilliant, but he also has a huge heart. He's on a mission, like so many of us, and he is reinventing the way we all look at exogenous ketones. So with that, I will tell you enjoy. This is an incredible episode. Welcome to the resetter podcast. This podcast is all about empowering you to believe in yourself again, if you have a passion for learning, if you're looking to be in control of your health and take your power back, this is the podcast for you. Okay? That one thing that's really emerging for me in in the world that I've been in with launching fast, like a girl, into the into the world, is that we need conversations around the information. When we look at health, one of the challenges we have is we go black or white. You know, a ketone is good or it's not good. You know, it's very like you want your numbers to be this. You don't want it to be that. And the human body doesn't work like that. Latt Mansor   No, it doesn't metabolism, I tell people all the time, metabolism is not a straight line. No, it is a flux. It's always ongoing, and you need to keep it in the Goldilocks zone. Is the optimal level of pH, optimal level of temperature, optimal level of amount of hormones that you're going to be in, amount of enzymes and you're going to be in. Just because something is good doesn't mean that more is better, Dr. Mindy   exactly. And so to that point, I feel like one of the challenges we have in the biohacking world is we understand something new about our body, and this could be something as simple as like we just discovered our hormones like testosterone. All of a sudden, we're like, I need as much of it as I possibly can get. Yes, no, no, you want to always be bringing these things into balance, and that's where the body really shines. So with that in mind, where I want to start this conversation is, what is a ketone, because there's so many people chasing ketones that don't even know what it is. Latt Mansor   So ketone is the brain's super fuel. Okay, why do I say it's a fuel? It's the same as every other form of fuel. You know, in the in the human body, we know the fuels are carbohydrates. Yep. Mm. Fats protein to a certain extent. Of course, our body will always try to preserve protein till the last bit. So mostly we'll be using glucose or fats right? Ketone works the same way. So ketones are broken down from fat, getting converted from fat in the liver, and enter the Krebs cycle the same way glucose and fatty acids would and provide ATP, which is the energy currency for the cell, right? Then a lot of people ask, why do we have so many different forms of fuels? It's because a good question. Yeah, it's a good question, because different situations would require different form of fuels. So when we use glucose, it's when we need fast fuel, because glycolysis the first part of glucose metabolism, you don't need oxygen to create that. So when you do intense exercise, when you go on anaerobic exercise, you will burn glucose first. For fat, fats account for 20 to 40,000 calories of storage in our body, versus 2000 worth 2000 calories worth of storage of glucose. So fats contain way more energy, but it's harder to burn. So when you go on endurance race, when you go on cardio zone two, that's when you tap into your fat storage. Now, I know you talk a lot about this on your on your podcast, when you are on a carb restricted diet, ie like keto diet, or when you're fasting, your body goes really low on carb storage and blood glucose, but your brain needs glucose to function primarily, right? But when you're low on glucose, what happens then? Like your brain can't stop working, right? So that's when your body says, Okay, I'm going to convert fat into ketones. Why can't fat just go up? Does the brain and get metabolized by energy? Because fats can't bypass the blood brain barrier, so it needs to be converted into a smaller size molecule, because fat has, you know, 18 to 20 carbons, sort of long chain molecule, so it can't get past because of the size of a molecule, so it needs to convert it to ketones. So it Unknown Speaker   needs, like a surrogate, like a surrogate, Latt Mansor   smaller size molecule, to get into your your brain, to be metabolized for energy. But then, over the years, we have seen research that shown that when ketones are present, the brain would preferentially take up ketones for energy. And in fact, I interviewed Dr Tommy wood this, you know, brain health expert from from Seattle. He said, When you know people go through brain injury, or an infant trying to develop their brain, they actually use ketone preferentially. So this is super interesting, because they are using ketones to re synthesize fatty acids that is used to repair the structural damage caused by the brain injury. Okay, Dr. Mindy   okay, hold that thought for it, because you just gave me a whole nother elevated okay. So if we are not putting ourselves in, I'm just going to say a fasted state, because that's the Dorian I've always looked at for ketones. I think it's the best Dorian take for ketones. If we're not, if we're eating fat, but we're not putting ourselves in a fasted state in order to signal to the body what to do with ketones. Then, is that fat more stored as fat? Do you see where I'm going with this? Like there's, there's an environment inside the body that needs to happen in order for that to signal, hey, we need ketones? Let's make ketones. I Let's use ketones. And if I'm like, go on the ketogenic diet and I bring carbohydrates down, I'm like, Oh, they told me to eat a bunch of fat. I eat a bunch of fat, but I haven't created the right environment in my body. Will that fat not turn into a ketone? Will it more likely turn into a fat molecule around my waist Latt Mansor   that I would say, No, it wouldn't unless you are having such an excess amount of calories that it forces your body to go into storage mode versus burning mode, because if you are having a maintenance amount of calories, for example, just the right amount of calories for you to just function and maintain your weight, then inevitably you will be turning that fat into ketones. Because either way, your brain will need that energy, and where is it going to get the energy from? Not glucose, because you don't have any, right? So it's going to to really pull from the fat conversion into ketones, okay? And then another interesting fact is that liver converts ketones into BHB, which is the sorry liver converts fat into ketones, which is BHB, beta hydroxybutyrate, the main form of ketone that our body uses. There are three forms, beta hydroxybutyrate, acetoacetate and acetone, but the main form that is getting circulated around and get metabolized by nd. Energy is beta hydroxybutyrate, and that's also why whenever you talk about blood ketone levels, when we test it, it's usually BHB level. The interesting fact is that even though the liver is a conversion organ that converts converts fats into ketones, it does not metabolize ketone as well. It does not have that sort of as much, and liver doesn't the liver doesn't metabolize the heart, the brain muscles, we have seen in heart failure studies that the heart, the failing heart, actually prefers ketones, probably because it's more efficient being used as a fuel per molecule of oxygen Speaker 1   use. So there are different parts of our body that prefer ketones correct over glucose. Yes, is it like? The brain is 5050, right? Like, Latt Mansor   the brain primarily uses glucose when you have glucose present, okay? But then when ketones are present, even when glucose is present, it takes up the ketone independent of glucose uptake, so it doesn't even affect the other substrates uptake, right? So, which means, you know that the brain really wants it, and you just basically providing extra energy for the brain to Dr. Mindy   work. So so I always go back to our primal ancestors, and how do they do this? And that actually makes perfect sense that the cardiovascular system would require it, because the longer you go without food, the more focused you have to become to find food, correct. So that's why the brain gobbles them up. But you're also probably running and chasing and going after hunting food, which is why it would go to the cardiovascular system. Latt Mansor   Yep. So you have two points there. One is the cognitive benefit, and the other is the energy benefit when it comes to performance. And we can talk about that with regards to exogenous ketones. But most importantly, one study by muchica paradi. Two years ago, they published a paper that showed keto diet and exogenous ketones and then placebo, three groups, right keto diet for a week, exogenous ketones, one dose, and then placebo. And then they measured functional MRI. They looked at the interaction of the brain regions, and they call it brain network stability. And this stability decreases as we age, and that's when you increase the risk of developing neurodegenerative diseases, okay. So what they have seen is that both keto diet for a week and one dose of exogenous ketones, they both increase the brain network stability. Speaker 1   That's crazy Is there a part of the brain that it didn't activate, they Latt Mansor   just showed the increased interaction between the brain region, so the activity, the brain activity increased, okay, so to your point, you know you are increasing your cognitive abilities, your cognitive sort of focus, but also because it goes into your Krebs cycle and produce energy ATP, especially when you need the cardiovascular fitness and cardiovascular performance, You have it. Okay? Dr. Mindy   So now, now I'm gonna go down this path with you. This is like, Oh my God, this would be like, what I do on a Friday night is having a conversation like this. It's very exciting, I know. So is it the mitochondria. If we look at we have the most amount of mitochondria. It, you know, in our brain, our heart, our eyes and our ovaries actually are in the female body. The eggs that live in our ovaries have the most amount of mitochondria compared to any other cell in our body. So my brain is thinking, Okay, well, if they're the most dense amount of mitochondria there, they need the most amount of ketones, yep, most amount of energy. That would make sense from our primal friends, because our primal friends need to stay alive, and the women need to stay alive and reproduce, so that we all could be sitting here today. So do we have any information on what ketones would do for the eyes or for the ovaries? Latt Mansor   That would be an interesting study. I've never I've never seen any studies specifically looking at that. But now that you mentioned the theory of it, I mean, theoretically it would work. It would need a lot of mitochondria. It will need a lot of fuel to fuel those mitochondria. And therefore the hypothesis would be like, if I'm providing ketones to the body, then I should be able to see the uptake of ketones in the eyes and ovaries at an exponential level. However, I think the feasibility of running those studies, I mean, because the heart they've done it in in animals, where they measure the blood going in, arterial blood versus venous blood, blood going out, and then that's how they measure the amount of uptake of different substrates, right? How would you do that with the eyes? I guess you can measure, yeah, Speaker 1   you can't be like, putting die. My ophthalmologist, you know, dilates and put stuff in my eyes. So maybe you can do the Dr. Mindy   same way. Yeah. But I'm even thinking for. Well, I'm thinking two things. One is, you know, as I went through my 40s, there's a moment that your eyesight goes and you can't read up close. But the more I've been practicing a fasting lifestyle, the more ketones that I put into my body. I'm just seeing subtle shifts, and one of them has been in my eyesight, like I'm not needing my reading glasses as much. And so the other day, I was wondering, I was like, What am I doing in my life that is allowing that to happen? So it would be really interesting to see how it how it works with with as far as eyesight goes. But the bigger elephant in the ketone room would be fertility, especially women that are do we and especially if we did, I mean, I know we're going to talk about like Alzheimer's and dementia, but do we have any way to measure if putting somebody in a ketogenic state or using exogenous ketones over a certain period of time helped with fertility? Latt Mansor   That's that's super interesting. I don't know per se. And I don't know, because I know for a fact that for keto diet, sort of ketogenic diet, studies, female bodies react differently, slightly different, compared to, yeah, to male bodies. And I think there is a paper that published the effect of keto diet on basal metabolic rate, basically the post menopausal women would be similar to males, yeah, but the pre menopausal women behaves completely differently, right? Speaker 1   I just had another thought, sorry, I have to get this out before, because you literally, I've studied this stuff, and now this is why I love talking to you like my whole brain is going to new. Okay, so when we look at the Women's menstrual cycle, when we look at day one, all the way through ovulation, which is the follicular phase, first 15 days, what's happening is estrogen is coming in in order to release an egg, and estrogen needs glucose to be low and thrives when ketones are high. And I'm wondering if that's because that's what the eggs need. They because they have so many mitochondria and Latt Mansor   they're also actively dividing, and really, yeah, Speaker 1   whereas the back half you're like the eggs already released, so it doesn't need that, which is why all of a sudden, progesterone wants glucose to be high. So you actually don't want ketones in the back half of your cycle, but it may all be based off of the egg. Latt Mansor   This is, this is how we run a study together. Yes, this is the conception of our our collaboration to run a study. Yeah, Speaker 1   because then we could look at something like your, you know, exogenous ketones, and we could say, Okay, how do we use that in an effective way to facilitate a better menstrual cycle and potentially better ovulation for a woman. And I mean, I have always thought of as exogenous, really helpful. I can see it for Alzheimer's and dementia. But now you got me really thinking that this, this could be a really powerful tool for fertility. And you also have me thinking, and I don't know if you all have thought of this, is that when we're looking at an exogenous ketone, it's probably best done in the front half of the cycle, and then the week before a woman's period, she would probably not use, she would cycle off of the exogenous Latt Mansor   Right, right, right? And that way you can have that predictable level of ketones in your body, right? Because when you use exhaustion, ketone is transient enough, and the effects is, the effect is acute enough for you to control when you need it to be on, when you need it to be off, versus when you're on ketogenic diet, you have that adaptation period, and then even when you cycle off, you'll have that adaptation period as well, right? So that gives you the flexibility to really switch on and off whenever you want to be in ketosis. So one Speaker 1   of the things that I that I did when I developed the fasting cycle in fast like a girl, is I tested it on a bunch of my team members that were struggling to get pregnant. Okay, and then, like, immediate I was like, let's try this cycle where we're gonna go high carb, low carb, and we're gonna do ketones in and out of ketosis over your menstrual cycle. Let's see what happens. I have a theory here. Okay, I'm like, I think it'll take us about 90 days to understand if this worked or not. Within 30 days, both of them got pregnant, and after, after trying to get pregnant for years, like these women were. So Latt Mansor   what was your theory? Then, when you when you ran that and you saw that result, what was Speaker 1   your theory? Then the theory was that estrogen wants glucose down and ketones up. Okay, and so when a woman is on day seven of her cycle eating pizza and ice cream, she's actually making herself more infertile, and she doesn't really realize it. And then the back half, the opposite happens. And so you want glucose up and ketones down, and I hadn't thought of it in terms of the mitochondria. Latt Mansor   Now we're going back into the basic science mechanism, mechanism of action, and that could be, why? Yeah, Speaker 1   so, so that. So then I was like, after I saw these two women get pregnant, I was like, oh my god, okay, let me try it on my patients. So I tried on my patients. Same thing everybody, like, 30 to six. Days, most of them 30. So then I went to my Youtube world and I'm like, let's try this. This was the birth of fast like a girl. People were writing in nd. Do you know right now on Amazon, my reviews on the book, I love reading the ones that say, Yep, I got pregnant in 30 days. But what do we do with your product? What do we do with exogenous ketones to facilitate that. Latt Mansor   Well, I mean, like, yes, like I said, you know, if you are going high and low, you know, manipulating glucose and ketone intake, you can use this to really boost the ketone levels on a transient level. Because what happens when you drink keto, exogenous ketone, like ketone IQ, for example, is that your blood ketone level, your blood ketone levels will go up to, you know, one to 2.5 millimolar over three to four hours, and it will stay above one hour if you're sedentary, if you're not working out, it will stay above one millimolar after six hours, and they will it will start dropping down to baseline, okay, and then after that, either you have to top up, or you Just let it, you know, just flat out on a baseline. That way you can measure, you can even like you can really solidify your theory about the ketones, right and glucose, and you can really pinpoint what exactly, Dr. Mindy   yeah, but I'm wondering if it's the health of the mitochondria and the egg. So if you have an eggs that are aren't viable. You let the root of that you have mitochondria that are dysfunction. Yeah. So, and then every woman who's struggling with infertility is going to have a little bit of a different dysfunction. So where I might need on day 10 to take in one bottle another woman might need, like three. So we, I think that's where the N of one comes in where you're going to have to figure out what that pattern is, Latt Mansor   and that's when it comes to sort of personalized medicine, and that's why I love talking to people like you have the ex the direct contact with people, and you touch people's lives directly, whereas I'm coming from a basic scientist point of view. And for you guys who don't know basic scientist means like scientists who always try to investigate the mechanism of action, we look at molecular biology, we look at animal models and really figure out what is actually happening inside mitochondria, what is actually happening with this particular molecule. Whereas clinical scientists are scientists who run clinical trials and look at effects on humans. So when we put one on one together, this world just, you know, we can start explaining the science behind this. Dr. Mindy   It's so funny you say that because this has been my new cry to my to people who are listening, is like, science gets us in the ballpark now we have to figure out what seat we want to sit at, and it's we have to take that and we have to apply it to ourself. But I fear that one of the things that we've done with science is we've held it up as the gold standard, and it's like, no, it's, it's just opening our minds. And to your point, we need each other in this conversation as the people listening. We need them as well to give us feedback so that we have some kind of understanding of how humans apply this. Latt Mansor   Yeah, because one is proof of concept and the other is translate the translation and application into humans life specifically. And as we know, metabolism is a beast. Yeah, when it comes to how to pinpoint and how to really fix, especially when you come up with dysfunctional metabolism, and there is level of severity, and you don't know where that level is, and then you need to get into the optimal level. Do you overshoot it? And when you overshoot it, it becomes another form of dysfunction, right? It's just a very difficult visa. Tackle, Yeah, Speaker 1   agreed. So, okay, let's go to the brain. Because now that we've geeked out on the ovaries and and, you know, the sperm, I don't know the mitochondrial makeup of sperm or testes, that would be interesting to know too, because this, you know, even though men don't have a cycle, you know, a monthly cycle. You guys have a daily cycle, Latt Mansor   right? So I would assume it will have high mitochondrial activity just because they're constantly being, you know, the DNA materials are being replicated and producing sperms, yeah. Therefore that activity would sort of be increased compared to the rest of your body, which is just, you know, as demand, right function, right? Well, Dr. Mindy   and the sperm need to be strong, yeah, strong swimmers, right? So there's got to be some mitochondria in there, because that's the battery of everything, of human life. Oh, yeah, 100% Yeah. Interesting. Okay, so take me up to the brain. When we say that the brain gobbles up my ketones. Do we know what part of the brain is gobbling the most Latt Mansor   that I'm not entirely sure. I do feel I do know that ketones does increase, BDNF, so brain derived neurotrophic factor and exercise also. Increase BDNF, right? And BDNF has direct effect on hyper hippocampus. Ah, okay. Hippocampus is also responsible for learning and memory, yep, so we know, and yeah, and I so I know that that region is very sensitive to ketone being available? Yes, and that makes sense, because in our $6 million contract with the DOD, we are currently looking at an exogenous ketones in cognitive and physical performance in hypoxia, and in the study we're wrapping up now, so we've got a lot of data already that's going to going to be published, but we have seen, when in hypoxia and in low oxygen levels, ketones actually increase memory recall as well as accuracy and reaction time, because normally, when you're in low oxygen level, your cognitive function decrease because your brain is saying, Hey, I've got less oxygen, and therefore let's lower the activity. And therefore that goes with the function. But we have seen the increase in memory recall as well as, you know, reaction time and all of that. And with all these cognitive studies, it just comes to show that hippocampus, you know, when it's when it comes to like memory and learning and mood and all that, as well as mood like I recently gave a lecture at University of Malaya as a fellow last month, and I brought keto IQ shots and gave it to the students. One of them actually said they had struggled with anxiety for a long time, but ever since he took the shot, 10 minutes after they took the shot, they stopped fiddling with their limbs, and they said it actually works. Speaker 1   Well, that's because ketones. I don't know if you know that when ketones go up, GABA goes Latt Mansor   up, yes, yes, on the GABA pathway, yeah, it's an angel lytic Yeah, because Speaker 1   I've told people that all the time, like, just sit there when you if, when you're in a fasted state, just tell yourself ketones are coming. Ketones are coming, yeah? And once they come, you'll go from this, yeah, to huh? I strangely feel calm, right? Latt Mansor   And this is the area I love to explain. I would love to hear your take on this. So ketones gets you into that relaxed state and calm state, right? But ketones also give you energy, yeah? How do you explain that? I'll give you my take off that you give, Speaker 1   I'll explain it by you have to. Ketones were meant for your survival. You had to go hunt, and so you can't be all frazzled, like, oh my god, I'm running out of food. I'm hungry. Ketones are like, boom. They're like, they put you in your body. They give you focus so you can go and hunt, so you can eat, so you can stay alive. That's how they were developed in our body. And so that they had to bring GABA up, they had to bring dopamine up, because dopamine is that motivation molecule is like, let's go get that food. That's all to me. That's what we're all searching for. And once we click in that ketone, we're actually in a hunter state. Latt Mansor   So you have to be calm, collected, focused, laser focused, and at the same time being able to really sprint out and use that physical prowess that you have in order to get that food. And the way I explain it is, especially when it comes to exogenous ketones, is that you need to stop thinking about it like a stimulant. It's not a caffeine. It's not a stimulant, so it's not actually giving you the extra boost by blocking adenosine receptor and make you feel less fatigued, but still not give you energy. That's stimulant, right? It increases heart rate, it increases blood pressure, but it doesn't directly give you energy. You still need to pull the energy from somewhere, yeah. Ketones directly gives you energy, but also gives you the signaling effect of the calming, the anxiolytic effect via signaling. And therefore you don't need to be in that jittery, like fragile sort of moment, like you said. And that's why you can use in both physically demanding situation, but also in a way, to calm yourself down, especially if you have anxiety. And I think a lot of people now starting to realize one good use of exogenous ketones is when they want to go for exams, interviews, podcast, because they're calm, but their brain is switched on so they can actually, you know, think better and really have the memory recall dialed in, but at the same time, they're not having this nervous energy that is stopping them from thinking clearly. Speaker 1   That the first time I learned about fasting and a ketone, I was experimenting it on myself, and I was trying. We used to give these big presentations to my patient base, and we would do a big one to hundreds of people every January to kind of set the year off. And so I wanted to bring fasting to them. We had just learned about Dr sumis work, Valter Longo come out with his three day water fast. Latt Mansor   So that's a very interesting point. We're gonna get into that one as. So, so Speaker 1   I was like, they're gonna think I'm crazy, because I've been talking about nutrition and detox, and now I'm gonna tell them that actually, all the supplements, all the food, things I've told you pale in comparison to what I'm about to tell you. So I went on a five day water fast, and on the fifth day, I gave the presentation. So I hadn't eaten in five days, and I did it on purpose so that I could show the my audience, my patient base, this is what it looks like to be on ketones. And so I give the whole lecture. It was a two hour lecture, and about 90 minutes in, I just said, and I know you probably think I'm crazy, and I want you to know, like, do I look tired right now? And they're all like, looking at me kind of funny. Are you sure you fast that for five days? Yeah. And then I just, well I did. And I just said to them, I was like, I haven't eaten in five days, yeah. And everybody was, was convinced at that point, and it was because I had ketones in me to so to give a speech, to stay calm. I wasn't hungry. It was a performance moment, yeah, and I think we lose sight of that, because everybody comes to ketones thinking, oh, I want to lose weight, but I always say, come, come in to lose weight, and then I'm going to ask you to stay for all the other benefits, Latt Mansor   right? Exactly the way I describe what is the use? I remember when we launched it early last year, we had a whole list of use cases and benefits of ketones, right? Yeah, you get the cognitive benefit you get, the performance, you get recovery, and then you get the metabolic health. But then, after all of that, it sounds like a snake oil. It sounds too good to be true. So right now, my favorite way of describing what's the best use case and what's the best benefit of ketone is that it will benefit you in any activity that you use your brain for, yeah, so either you're using it for intellectual, cognitive performance side of things, or if you're using physical side of things, because even when you're doing physically demanding tasks, you still need your brain. People on long rides, on long runs, they still need that focus. People on trail runs, they need their sort of alertness and focus of their surrounding, their balance and everything. People who are doing anaerobic exercise, they still need to be in the zone to get the form right, to think of all everything you know, the weights and all of that. So Speaker 1   you're in your primal state. You're in your primal state. So okay, now I'm gonna really geek out on a part of the brain. Yeah, I have been currently this week, writing a whole chapter for my new book on all right, and you're Latt Mansor   on the road. Mindy. You are always on on it. You're always on Speaker 1  Well, I love to solve problems that that our culture isn't solving. And one of the biggest problems that we see right now with women going through menopause is that there's this massive brain change, and one of the pieces of the brain is a receptor site known as 5h, two, A, which is a serotonin receptor site, and estradiol goes into that and activates serotonin, which helps with keeping us joyful. When estradiol goes away, we have this empty receptor site. So I've been looking at what else do we have that can go into this receptor site? Well, one study that I came across was that something as little as eight hours of fasting will activate the serotonin 5h, two, a receptor site, and now in the nd, regardless of what diet they are, regardless of what diet, eight hours seems so minimal, just sleep overnight. Yeah, and it's in the hippocampus that because we have five to h2, a receptors all over our brain, but it's in the hippocampus that it activates, which is why they actually think fasting isn't it can act as an antidepressant, but I'm thinking it's because the ketone goes into that receptor site. So do you know any studies on that receptor site and ketone? I haven't, Latt Mansor   I haven't seen any anything specific to that receptor side. And I'm, I'm and I know, in terms of receptors, things are very specific, right? It's very unlikely that a foreign molecule will bind to that receptor site. But then again, a lot of studies also shown that ketones have direct effect on DNA as a signaling molecule. They call it beta hydroxybutylation, because we know methylation of a DNA and it causes, you know difference in gene expression, right? So they found out that beta hydroxy butylation is the thing. Now it's a mouthful, yeah, Speaker 1   just say BHB relation, yeah. So I like this short. Latt Mansor   It does have effect by binding on sites that we didn't know that they bind. So I think the area is still very new. And I spoke to my my supervisor back in my PhD days in Oxford a couple of months ago, and she's still in the research area, and she's like, the next big thing now is metabolites as signaling molecules, because we need to stop looking at all these metabolites do. As energy fuels. We are looking at it as signaling molecules, like how glucose does not only provide you with energy, but it's going down this cascade of pathway that's, you know, working in tandem with insulin, glucagon, GLP, in in a different sort of setting, and cause a whole different phenomenon of inside your body. Speaker 1   Okay? So, yeah, oh, my God, I can talk to you forever. So this is leads me to the next question, which is, is there an environment in which an exogenous ketone is welcome in our body, and is there an environment when it's not welcome, like when I first heard about taking an exogenous ketone, honestly, my first thought was, well, that's cheating, and I'm, like, a hard working Latt Mansor   so many people say that. So many people, why would I take exogenous ketones when I'm burning my own fat and turning it into ketones? And that's an easy question, right? If, let's say, if you are going on a ketogenic diet to lose weight, all right, the goal is for you to access your fat storage and turn it into ketones and also burn the fat directly, right? As an energy fuel, sorry, as an energy source. What are you eating? Mainly, fats, right? Your own fat, your own fat, they're calories, right? Yeah, I guess they are exogenous ketones. They are source of calories, right? If you want a ketogenic diet to get into ketosis, you're gonna get the source of calories anyway. Why not have a portion of that be a direct form of ketone? Speaker 1   Okay, so, but what if my blood sugar, if I just ate a meal, my blood sugar went up. So now I've got all this glucose for the body to use, and then I toss down some exogenous ketones. Latt Mansor   That's another use case. So studies, a few papers, have been published by Dr Jonathan little from University of British Columbia, Canada. When you take exogenous ketones across the board, they have seen lowering of blood glucose. Oh, my God, this is acute. And you can, you know, you can take my word for it, because we've measured it ourselves. We've had people a ketocon when I met you. Yeah. We've got people with continuous glucose coming up to us. We gave them a shot. We're like, come back in an hour, and let's measure your glucose, and it dropped 40 to 50 points. Speaker 1   It's like apple cider vinegar. It's like apple cider vinegar to everybody, by the way, just so you know, I do, I do all these science dense videos on YouTube, and they do well, and then I do throw out apple cider vinegar, and everybody goes crazy. Latt Mansor   Yeah, I had my CGM a couple of days ago, and I drink ketones before I go to bed, and then it start asking. The app asked me, is that, what did you do? Your glucose was 70 when you go to bed because I drank ketones, but at the same time you don't feel the hypoglycemic effect? No, I never thought so. One hypothesis that the scientist that Dr Jonathan little, sort of hypothesized is that when you take exogenous ketone, you are sending signal to the liver to lower gluconeogenesis. Gluconeogenesis is a process of making sugar from other sources, like glutamate, from, you know, fats and proteins and all that. That is especially true when you are on ketogenic diet or when you're fasting, because either way, even when you're on low glucose, you measure your blood glucose, you still have a baseline. You'll still have about four or five millimolar Okay, right? Where does that glucose come from? You're not eating right sugar, so it's from gluconeogenesis. I was just gonna say, yeah. So gluconeogenesis also happens at all times, even when you're eating sugar. Okay, so your body balances it, right? It balances it by saying, okay, these are the external sugar. I'm gonna use it. But at the same time, it's a flux. It's a balance of you producing your own sugar. Same with fat. When you take in fat, it does not just go into your muscles and get used, right? It gets repackaged, it gets redistributed into the body and churn it round, right? So this is what they hypothesize. When you have exogenous ketones, you're lowering that glucose production in your liver, and therefore it reduces the overall blood glucose level, but that also shows that your body perceive ketones as a energy source, that you have plenty, that you don't need to produce the glucose anymore, right? So that's that's the main point here, exogenous ketone and endogenous ketones, while it is a little bit different in nature, because you're not producing yourself. Ultimately the molecule is the same, so your body will still recognize it as ketones. BHB is BHB is BHB is not a novel magic molecule that the pharmaceutical company whips up from a genetic modified D. Organisms, it is literally the same exact molecule that your body would produce. Speaker 1   So a big challenge that a lot I see with a lot of fasters is that when they eat dinner, their glucose goes up, and then they go to bed, and somewhere around two to three in the morning, all of a sudden, the blood sugar dipped so much that it causes this. I mean, it's the dawn effect, right? The liver secretes a bunch of glucose into the system in order to be able to, you know, regulate itself. They wake up at two or three in the morning. They get it the next, you know, when they actually wake up and get out of bed in the morning, they look at their glucose and they're like, Oh, my God, it's higher than it was before I went to bed. So if that theory you're talking about is right, could we use exogenous ketones before we go to bed to stop that two to three wake up that the liver does, because now the liver has a sensor that tells it you don't need Latt Mansor  I can literally show you my glucose data right now, like, when I'm, like, asleep, like, it literally flat, flattens out. Speaker 1   That's so, oh, so you don't even when you're sleeping, it doesn't even have, like, spikes up and down, like typically. See, have you tested it on, like, your aura ring? Latt Mansor   Um, I, I have Yes. Um, it hasn't shown an improvement. I mean, we tried doing it in a study as well to look at HR V and all that, sleep quality wise, we are still a bit far from from being able to test how effective it is, but in terms of blood glucose levels, yes, yes, so we know that it flattens out when you sleep. Speaker 1   And so there's two new places that I've never, ever thought to use ketones, that you've really expanded Well, I think we have more than two, but right now, in this moment, I have two, which is before bed for sleep, which I just want to tell you, for menopausal women, that would be a game changer, because as we lose progesterone, we also don't go into as deep of a sleep, And then after a meal, after a meal, yeah, bring down glucose. Yeah. So then my brain goes to because Latt Mansor   I love and then the interesting thing, another way you can check is when you work out, like halfway into the workout, into the end of the workout, you'll see your glucose go up a little bit, because your body starts sending signals to say that, hey, you are doing something physically demanding, therefore creates more glucose, right? But when you have ketones as a pre workout, you don't see that spike. Oh, but you have energy, Dr. Mindy   okay, so, but as a pre workout, if I've got ketones in there, I'm not gonna get as much release of sugar out of the muscles. And maybe I want to, like, show more definition. So I kind of want the release of muscle, of glucose, so that it like, breaks down fat. Do we have any research on, like, what it does, as far as muscle, maintaining muscle, as far as you know, leaning muscle out? Latt Mansor   So there is a study that looked at another form of exogenous ketone, aceto acid diasta. They looked at cachexia, so muscle loss due to cancer, and they shown that ketones actually help retain muscle. And we know that from a recovery point of view. There is a study that looked at having ketones together with protein and carbs after a workout, and they looked at it from an in vitro point of view, looking at biopsies of muscles, they actually up regulate the Luci mediated amtor activation, and that is essential for protein synthesis, which is also essential for Speaker 1   recovery. Wow. So if I'm going in a three day water fast, and I don't want to lose a lot of muscle, then take some exogenous ketones. Is preserving that much, correct? Latt Mansor   And a lot of people ask the question, will I bring my fast because it contains 70 calories? And Cynthia Othello and myself, we talked about this on our podcast. Is that when you are fasting, when you go in on water, fast, what? Kick Start? The ketone ketogenesis, right? The ketone production, it's when you're low on sugar, when you're low on insulin, right? You starving yourself, and therefore your body kick starts. The ketogenesis, when you have 70 calories of ketones. It doesn't increase your glucose level, it doesn't increase your insulin level. There is no reason to believe that you won't kick start your ketogenesis. But also, this brings back to the conversation of Malta, long I was just gonna say, long ago. Studies fast mimicking diet. They are giving these participants 500 to 750 calories worth of food, and they can still mimic the effect of water fast. So 70 calories is nothing. Unknown Speaker   You'd have to have 10 of those in a day, 10 of Latt Mansor   those and also acutely. What they have seen in animal models is that when you take exogenous ketones, you are up regulating all the transporters. Enzymes which are relevant to ketone metabolism, which means, when this is transient, after six hours, it goes back down to baseline. You are now tapping back into your own endogenous ketones. You have up regulation of all these different enzymes that's needed for keto metabolism, so you are primed and ready to burn more ketones from your own body. Speaker 1   Oh, my God. Now you have me thinking like, Well, why would you fast without exogenous ketones? Like you like, it's next level. It's next level. Okay, so then where would we? Where would we use this for, like, Alzheimer's dementia? I hope everybody listening it knows how I'm going at this from menopause and women now, and I hope people take this seriously and try it with like fertility and things like that, but let's talk Latt Mansor   about love to find out more about that. Yeah, that's not my area of expertise. And I know a lot of our audience are also women who are interested in metabolic health, especially you know, as we are aging, we know that all these different risks and all these different foods that we're eating that puts us at risk, right? So I would love to hear more, you know, after you experiment with it, and really like real life examples, real life cases are what's gonna move the needle? Speaker 1   Gonna do it? Yeah? Well, we'll put the links to your products in there, so people listening, please go, go, try this and see. Because fertility is expensive, yep, and it's, it's, you know, breaks people's hearts and and yet the the body was meant to reproduce. So if there's an issue where the body's not able to reproduce, then we got to fix that, and it's coming back to a molecule that's as innate in our body as our blood is, is a ketone, and yet the world, half the world, is not even getting the ketones. Latt Mansor   Disclaimer, though, it does not taste like soda. It does not taste right. We are working on the flavor, but knew this the reason why we are surviving and thriving is because when people take it, they feel the subjective difference, and regardless of the taste that people are taking it for the benefit, yeah? And what's very, very funny is that most people that have been taking it long term now they're like, actually, I don't mind the Dr. Mindy Pelz   taste. Yeah. You get used to it. Yeah. That. I could totally see that. Yeah. You know what I always say when you, like, take a shot of something that's healthy and you're like, Oh, I hate that. I'm never gonna do that. I always think, Well, what did you do in college when you're at a bar and, like, they gave you, like, exactly, you take it for the effect, like, you didn't just, you didn't go, oh, I don't like that. You're like, give it to me. Feel good. I want the effect of it. So Latt Mansor   that's a great example. That's a great What did you think when you would What were Unknown Speaker   you thinking? What would you tell your 21 year old son? Latt Mansor   Yeah, so now, now we're talking about therapeutic users. Yeah, because Thank you. Know, Like, like, what we're saying, everything that uses your brain, every activity that uses your brain, you can benefit from having ketones in your body. I don't care whether you get your ketones from keto. Ketogenic diet or fasting or exogenous ketones, as long as you have the molecule in your body. Yeah, you will, granted, you need to get at least above one millimolar right in your blood for your butt. Speaker 1   Like, okay, wait. Why? Because the the measurement people in my community Latt Mansor   zero by five, 0.5 Yeah. But Unknown Speaker   everybody's like, well, more is better. Latt Mansor   Okay, great, great conversation. Okay, so the definition of ketosis is anything above 0.5 right? But for therapeutic users, a lot of studies shown around one millimolar. Anything above one you start to see effect already. For performance, we're looking at above two millimolar. Oh, wow, okay, above two millimolar, but also not meant to subsidize or replace glucose. It's meant to be used together so that you you have the hybrid fuel system. And, yeah, I know you want to talk about this, about high sugar, high high ketone levels, right? We can go into that later. But most importantly, when we talk about the threshold, we want to make sure that it's in the optimal level. Like I said before, right metabolism is in the Goldilocks zone, yes. And the reason why I tell you more is not better is that we have seen this in study, and this, I can say confidently in the military study, we dose them via weight match dose. So we do 0.5 grams per kilogram of body weight, which means some of these guys are big. They're like 8090, kilograms, right? So you are getting ketone esters. That study we use in ketone esters, they're getting about 4050, grams of ketone esters. And one disadvantage of ketone Ester, the advantage of ketone ester is that it can spike your blood ketone levels between three to five millimolar, quite high, quite quickly. Ketone IQ is not ketone ester. Ketone ester is a bhp molecule bound with butanediol in a. Ester form. So that's why it's called ketone ester. What we have found is that because it spikes it too high, it also increased blood acidity. It lowers blood pH, because BHB is beta hydroxybutyrate acid, and it does cause your blood to be acidic by the body. So over time, when you spike it too quickly, in a short amount of time, you increase your cardio respiratory stress biomarkers, your heart rate, your breathing rate, because you're trying to expel the carbon dioxide to neutralize it, but most importantly, because half of it is butanediol and half of it is BHB. The BHB goes straight into your blood, which means it's dose dependent. So the more you drink, the higher your BHB will go. So initially we thought, the more the better, right? The higher the better. No. So some of these people were having blood BHP of 678, millimolar, and they start to not feel well. They just feel unwell in general, just wanting to puke and just your body trying to expel it, because it's just too much. Yeah, it's the same when you overdose on glucose, right, right? You when you have too high, you just don't feel well. It just generally you feel unwell. And I think this is the case with ketones as well, even though it's good for you, even though it's this energy source. But if you're not using it, it's just sitting around, your body will try its best to balance it out in in homeostasis and into this, this optimal zone? Dr. Mindy   So what this actually leads me to a unique question that I've seen with just a handful of people, which they feel worse in ketosis than not in ketosis. And my brain was always like, okay, the ketones are going they're going to repair something. So what needs to be repaired in the body? Yeah, but what, based off of what you just said, even if somebody's at like point 7.8 is it possible that that could be too many ketones? Um, Latt Mansor   from what I've seen on the overdosing is usually five and above, right? So if they're on round point 8.7, and not feeling well, chances are I think they are just doing it too quickly, the adaptation period. They're not used to it. Therefore they're going through the Keto flu. So it could be something to do with the electrolytes, something to do with dehydration, because when they lose glycogen, when they first go on keto diet, they shed all the glycogen off with glycogen, it also comes with water storage, right? So it could be Speaker 1   that, do you find that? Do you ever see the Keto flu with exogenous ketones? Because, no, I don't hear about the Keto flu very much anymore, but I, like I said, I am seeing some unique cases where they go into ketosis and they you know, my my theory is, you go in, you go out, you go in, you go out. And so in these cases, were doing that for a very long period of time, but they're still not feeling well in the ketogenic state. So, but that would fall under the category, category of a Keto flu. So if I gave that person, if I fed that person, fed them breakfast, that's that's one, yeah, go ahead, yeah. Fed them breakfast and then gave them exogenous ketones so that they get the benefit? Would there be a different response? Latt Mansor   That's the perfect way to find out whether if this person is feeling unwell because they are, if it's too high ketone levels, or if it's ketone flu, because with exogenous ketones, it's predictable. You know, you will get the ketone levels above one or close to one. If they're still feeling unwell, then it could be the ketones. But if they're feeling good, then the ketone is doing the work, but they're not going through any electrolyte Speaker 1   problems, changes, okay, this leads me to my next question, which is, could you and you know, I'm not advocating for not fasting, because I think there's so many therapeutics, but, but let's say that everybody decided I don't want to fast anymore, and they just wanted to eat again, and we gave everybody a bunch of exogenous ketones. Are we getting the same benefit when we take an exogenous ketone as compared to the in endogenous ketone, are they? Are they the same benefit? Latt Mansor   That's a great question, Mindy, and this is a question that I've been asked a lot because a lot of people like, oh, there's cheating. You know, I'm not achieving what I trying to achieve with keto diet. So when you look at the molecule, like I said, it's going to be the same molecule. And therefore, if you're looking at any signaling effect or any energetic point of view, it's still going to be the same. You're still getting the energy from ketones. You're still getting the preferential treatments in different organs with ketones, and you're still getting all the signaling benefits from ketones. However, whenever you're doing keto diet, for a specific reason, I reason you may not be able to achieve that with exogenous ketones, and I'll tell you certain situations here, if you are specifically aiming for lower glucose level and lowered insulin level, yeah, you can't get that with exogenous ketones, even though ketone exogenous ketones. Can acutely decrease blood glucose level. It does not have any effect on insulin, right? So if you're still on a normal diet, you are still going to be regulating the blood glucose, the glucose you're getting from the carb intake, as well as your insulin. Speaker 1   That's because the body, by the way, that's because the body is so smart, yeah, that the body's like, I don't need to make insulin, right? Because this came from the outside, Latt Mansor   right? And then you get epilepsy treatments with keto diet, I don't think exogenous ketones would be as efficient, because you need to be. That's another thing in terms of prolonged period in ketosis, because when you're on exogenous ketones, you need to top up regularly to be in the ketotic state in a more consistent way. Whereas ketogenic diet, you don't need to think about it. Don't need to worry about it. If you want to get into a deeper ketosis, you want to reach a higher blood ketone level, then exogenous ketone could help augment that, right? But it may not help you achieve whatever you're trying to achieve by getting on a keto diet or fasting. Because if you say fasting to lose weight, right? You are, mean, you are. You are emphasizing on lowered calorie intake, lowered insulin and all of that. It's very unique to fasting. So I want people to think about ketones, not just as a magic molecule. Think about it as a tool that's helping you to achieve what you want to achieve, if you're fasting, to lose weight, but because ketones, exogenous ketones, have appetite suppression effect, and it gives you the focus to augment your fast. Go, do it right, right? Don't not fast, just because you can get the benefit briefly, just Speaker 1   from you can't sit on your couch and eat a bunch of pizza and ice cream and drink Latt Mansor   ketones. It's not a magic molecule, right? You still need to do that foundational work. If you know you want to lose weight, you still need to go exercise and all of that. Speaker 1   The way I look at it is that when the body makes endogenous ketones, it's making it because it's burning fat. So if you're trying to lose weight, to your point, you just drinking a bottle of ketone. IQ is not going to be like, Oh my god, now I'm all of a sudden Latt Mansor   losing weight. And it is it is calories, it is calories, Speaker 1   but what it is doing is it's killing hunger, yes, and what it is doing, we just discovered it, or I just discovered, is it's lowering blood sugar. So it is a part, like you said, of a tool to be able to put you on your weight loss journey. It is not the thing that it's not like the thing that's going to make you lose weight. And Latt Mansor   just a sneak peek, currently, I'm talking to a researcher from UBC as well who looked at the blood sugar lowering effect. I'm talking to another researcher within the same university. We're looking at running a study specifically on appetite suppression, on hunger hormones, on ghrelin. And there was a study that showed that butanediol, specifically, which is the raw ingredient in ketone IQ, increase leptin sensitizing effect in the brain, which means you feel more satis, you can have higher satiety compared to placebo, and we're looking at calorie intake as well. So when that study published, it's going to be huge, because then now people can confidently say, Hey, I'm taking exogenous Ketos, not as a replacement of my lifestyle, of my Keto diet, or of my fasting lifestyle, but I'm using it as a tool to really augment it. Make my fast easier, because I don't have to think about food all the time. I get the focus I need. I get productive throughout the day. And same thing, when I'm on ketogenic diet, I feel like, you know, I'm not getting in deep enough ketosis, so I'm augmenting with exogenous ketone, or I am going through this really difficult adaptation period, I'm taking ketone IQ so that I can up regulate the enzymes needed to prime my body to be able to metabolize ketone better. Speaker 1   Well, I'll tell you, like, I'll use myself as an example. Yesterday, I had a really long day and I didn't get enough food in me. I woke up I was a little hungry. I was like, Okay, what are you gonna do? You know, I interview here with you. I've got one in a couple hours. I'm like, What am I gonna do? Am I gonna eat? Am I gonna eat? And then we, we took a shot of keto, ketone IQ. I'm not hungry anymore. Latt Mansor   I don't think about it. And after this, Kelsey and I, we're gonna go work out and film some contents, and I'm definitely gonna take another shot. But I'm not hungry. I'm not thinking about food. Speaker 1   Yeah, it's really cool, because it does turn off that hunger hormone. So it's quite impressive. Latt Mansor   The interesting thing as well, sorry to cut you off. Yeah, no, is that, while it turns off the hunger sensation and it keeps you satiated, in a study that looked at recovery when people are exercising. Then they increase the calorie intake. The participants, the cyclists, were given food at libertum so they can eat whatever they want, however much they want. But because they're exercising, they are actually increasing their calorie intake. But also, corresponding to that, they increase their performance by 15% in terms of work output after three weeks using after using ketones, carbon protein as recovery. Wow. So the way I like to describe ketone is an adaptive fuel. Yeah, it up regulates and down regulates things in your body, depending on what you're doing. Speaker 1   Would you take it every day, or you just, I take it every day? Yeah, and you would, do you do it intentionally, like, I'm gonna go work out, correct? Hey, I'm gonna be on a podcast. So it's a performance enhanced. Some, some people Latt Mansor   take it on a just in the morning, just, yeah, just as a ritual kind of thing. I prefer to take it on a very intentional, like, I'm going on a podcast, I'm gonna take this, I am going to bed. I'm gonna take this, I'm gonna go work out. I'm gonna take this Yeah? So that, for me, has worked, but I also know a lot of people on our team themselves, they just take it one shot in the morning just to keep themselves productive. Yeah? And that's why it's very interesting, because you can use it as pre workout and before bed. Speaker 1   Yeah? So Okay, I gotta summarize this. We've talked about it potentially helping with with infertility because of the denseness of the mitochondria and the eggs. So everybody go try that. We've talked about it for depression because of its what it does in the hippocampus. We've talked about it for lowering blood sugar post meal. So we can put weight loss, you know, gosh, weight loss is all over this conversation, whether people realize it or not. We've talked about it taking down hunger. We've talked about it helping with sleep, so you don't create gluconeogenesis at two in the morning. Performance when you are when you're actually going to work out, upregulating these ketones. Anything I'm missing? Brain health? Brain Health? Latt Mansor   Yeah, we talked about Alzheimer's brain injury, happy DNF, and how ketones are actually taken up by the brain to create the fatty acids needed for structural, structural repair right of the brain. Yeah, and then, and then, that's very important for Alzheimer's dementia, or all these neurodegenerative diseases, those are the areas we talked Speaker 1   about, and cardiovascular system that was new. You taught me that today. Yeah, so and what I love, and I hope people are gathering this, and this is my jam, just in life is bringing two people that are passionate about similar things together and going, Hey, how does your work and my work come together so that humanity can win? Yeah, let's change the world. Yes, exactly. So okay, I have to finish on this comment these, there are these questions. This is my theme for the for the year, is self love. So we're gonna take it away from ketones, although I do know the ketones are a form of self love, so the challenge Latt Mansor   is for me to take it back into ketones, right? Yeah, right. Speaker 1   You can answer this without the letter K coming out of your mouth. Latt Mansor   Your audience should have a drinking game. Every time we say ketones, they'd have a shot. I'm sure they'll be floored by the end of this talk, yeah? Speaker 1   Or they're gonna be like, so like buzzing that they're not gonna they're not. They didn't stick with the podcast. They probably went out, worked out. Yeah, do you have a self love practice? And the second part of that question is, what do you think your superpower is that you bring to the world? Latt Mansor   Oh, boy, I Okay, let's, let's go to the first part. First, I think self love. I always thought I I have self love, right? And I grew up like I said, my family side has high prevalence of chronic diseases, so my mom's side has has really high prevalence of obesity, and I grew up overweight all my life. And this is a story that I share a lot with Ben Azadi, because he has gone, yeah, he's got a huge, a huge weight loss journey. Yeah, so I used to hate how I look, and I worked out and worked out and improve how I look, because I hated what I was or how I looked before, but now it's just a simple switch of perspective. I work out and I want to be healthy because I love myself, because I was given this body, this metabolism, this family, this genetic and there's only one of me, so why not love myself enough to make a change? Why not love myself enough to do something good for my own body, and I think that's from a physical point of view, yeah, and mentally, I always thought I loved myself as well, but then I realized I didn't until two years ago, because growing up in Asia, you. Your self worth is most often than not, tied to materialistic stuff. Your parents would love you more if you go to a better university, if you get straight A's, if you become a doctor, an engineer, a lawyer, that's pressure good paying job. And I'm sure a lot of people grow up in Asia, even here in America, you know, some families, they can relate to this, right? The tiger mom, right? And I know my mom wants the best for me, and my parents wants the best for me, but at the same time, that became my foundation, right? So I tie my self worth to all of these things, but then I never love me for being me. So I started meditation two years ago now, although I could be more consistent with it nowadays, and it really took me out of that inside view to a third person point of view, if you would, I'm able to zoom out and look at that and realize that, and just realizing that, I think the first time I meditated, I cried because it was, it was a guided meditation. It says, Put your hand on your heart, love yourself and be compassionate with yourself. And then that was when I realized I never did. I loved people my accomplishments. I loved where I got in life. I loved what I am in terms of, I'm a scientist, I'm an educator, I'm a science communicator. I never loved lat Mansoor. Oh, I forgot about it. And that was when I realized, and that's when everything else does not matter, not money, not fame, it's what I do, what I'm passionate about. And when I leave this world, I ask myself, I always ask myself, if I die tomorrow, will I have any regrets? And this, and the goal is always to say no, that you've done everything you could and full of love for yourself and for the people around you. Yeah. Speaker 1   So, oh my, that's the best that was, like, the best answer I've been given all there's been some good answers. Okay, Latt Mansor   does this fit for the inaugural in person interview? Speaker 1   Tell me what now. Tell me what your superpower is. I think I just found Latt Mansor   my superpower. I think my superpower is something that I really cherish, is the ability to connect with people. Yeah, because when I was overweight, I was always that friend that people can count on, but not that friend when, when people want to have fun with or when, when, you know I'm that, that overweight friend who's like, oh, you know, lots good with his homework. Let's talk to him when we need him academically, you know, because it's smarter. But when it's like, oh, he's not the cool friend, you know, he's not the cool guy. But that helped me develop my personality. That helped me to come out of my shell, be an extrovert, and that helped me really put an effort into how do I connect with people? How do I remember first and first and foremost, always remember the person's name. Yes, people always appreciate that. Yeah. And then you think about, what are the common things that you can connect with, that you can talk about. I'm always conscious of that and intentional when it comes to that, and then when you connect, everything else is magic. Yeah, agreed. I think that for the worse or for the better, that was not the most, you know, some of the experience were not the sweetest, but the lessons, nonetheless, was something that I can take with me for the rest of my life, and I will forever cherish Speaker 1  Yeah, that was the most beautiful, literally, the most beautiful answer that I've been given, and and is at the heart of why I do what I do because we have a culture that looks at skinny, beautiful and says that's successful cars you drive. That's what we're all going for, and we lose sight of the MO The bumps along the path, and the internal conversations we have with ourselves and how we start to orchestrate a whole, our whole life around those internal conversations. So what I hope everybody gathers from what you just said is you had some really rough moments, and you changed the internal conversation, and that changed your Latt Mansor   life. Yeah, and no matter what kind of experience you have, bad or good, it's still part of you, and it's what makes you you now, and what matters is now. Yes, not the past, not the future, it's now. What you do now matters most, so focus on you now. Whatever you can do now, just do it for yourself, for your people that love you, for for people who. Who are around you, and even for people who do not love you, prove them wrong. One Speaker 1   of my favorite quotes, I'm a big quote fan, is, don't, don't think about what the world needs. Think about what lights you up, because what the world needs is more people that are lit up. And that's, that's the that's the goal, to me, that's what we're working towards. So how do people find you lot? This was just incredible. Latt Mansor   Can find me at lanso, l, A, T, T, M, a, n, s, O, R, on all social media platform and also H, V, M, N, podcast on Spotify, Apple podcast, all podcast platforms as well as YouTube and Yeah, send me messages. I do answer them and comments and Speaker 1   happy to share Yeah, and test everything we talked about out and then give us both feedback. Latt Mansor   Yes, amazing. Appreciate it. Thank you Speaker 1   incredible. Thank you so much for joining me in today's episode. I love bringing thoughtful discussions about all things health to you. If you enjoyed it, we'd love to know about it, so please leave us a review. Share it with your friends and let me know what your biggest takeaway is.